Schistosomiasis: A Multiplicity Of Immunopathology

Immunopathology of schistosomiasis mansoni in mice and men.

Padraic Fallon recently presented an excellent summary of cytokine responses and immunopathology in infected mice and humans1. We wish to take issue with several points, including Fallon’s implication that morbidity and death in immunodeficient mice caused by type 1 cytokine responses is relevant to human schistosomiasis. In this model, hepatocellular toxicity1,2 is apparently caused by Schisto...

A Role for Peroxisome Proliferator-Activated Receptors in the Immunopathology of Schistosomiasis?

Peroxisome proliferator-activated receptors (PPARs) have been demonstrated to have a role in immune regulation. In general, they are anti-inflammatory and promote Th2 type responses, and they are associated with the alternative activation of macrophages. Interestingly, helminth infections, such as the schistosome blood flukes that cause schistosomiasis, are characterised by a Th2 response and t...

Murine Schistosomiasis Immunopathology and IL-17 Production in Genetic Control of Severe Egg-Induced Stadecker

The immunopathology of human Schistosomiasis-III. Immunoglobulin isotype profiles and response to praziquantel.

Immunoglobulin (Ig) isotype (IgG, IgG1, IgG2, IgG3, IgG4, IgM, IgD and IgE) levels were investigated, both pre- and post-treatment with praziquantel (PZQ), in 43 adults and children chronically infected with Schistosoma mansoni, by means of a two-site, isotype-specific immunoenzymometric assay. The patients were classified as responders (R) or non-responders (NR) on the basis of their circumova...

Immunopathology.